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1996-03-09
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Document 0373
DOCN M9650373
TI Reduction of HIV concentration during acute infection: independence from
a specific immune response.
DT 9605
AU Phillips AN; Department of Primary Care and Population Sciences, Royal
Free; Hospital School of Medicine, London, UK.
SO Science. 1996 Jan 26;271(5248):497-9. Unique Identifier : AIDSLINE
MED/96152367
AB After infection with the human immunodeficiency virus (HIV), the
concentration of the virus in the person's plasma increases. The
subsequent decrease in concentration a few weeks later was though to
result from an HIV-specific immune response. This purported causal
relation is investigated with a model of the dynamics of early HIV
infection that incorporates no increase in the rate of removal of free
virions or virus-infected cells. A pattern of changes in virus
concentration similar to that observed in patients is predicted by the
model. Thus, the reduction in virus concentration during acute infection
may not reflect the ability of the HIV-specific immune response to
control virus replication.
DE Acute Disease CD4 Lymphocyte Count CD4-Positive
T-Lymphocytes/IMMUNOLOGY/*VIROLOGY Human HIV/*PHYSIOLOGY HIV
Infections/IMMUNOLOGY/*VIROLOGY Lymphocyte Transformation Mathematics
*Models, Biological Population Dynamics Viremia/IMMUNOLOGY/*VIROLOGY
Virion/PHYSIOLOGY Virus Latency Virus Replication JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).